Ankylosing Spondylitis

This is the primary inflammatory polyenthesitis of the spine. Inflammation in most other tissues leads to their destruction but this not the case in the spine. The opposite occurs whereby enthesitis is associated with florid tissue repair and new bone formation at entheses. When inflammation is controlled in Rheumatoid Arthritis then joint damage usually stops but in Ankylosing Spondylitis damage as determined by loss of function due to the bones knitting together may actually get worse. Key to understanding these processes is the central role of the enthesis in health and disease.

AS Overview

Ankylosing Spondylitis is associated with enthesitis at multiple sites. It is the commonest inflammatory polyenthesitis of the spine. It has a predisposition to involve entheses of the spine from the low back where it most typically starts ....

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Enthesitis at AS Onset

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The Sacroiliac Joint

The sacroiliac joints links the spine to the pelvis and is a major cause of back pain and especially pain in the low back. The sacroiliac joint is lined by synovium and produces lubricating synovial fluid ...

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Why did my AS start in the Sacroiliac Joint

Ankylosing spondylitis (AS) typically starts with low back pain in the sacroiliac joint. This page helps explain why ankylosing spondylitis starts in the sacroiliac joint ....

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Chest Pain in AS

The chest wall is an incredibly complex region with multiple insertion points that may become inflamed in Ankylosing Spondylitis and related disorders. The purpose of this page is to explain to both patients and doctors why chest wall enthesitis is frequently not recognised ....

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Eye Disease in AS

Acute anterior uveitis causes pain, redness and loss of vision due to inflammation in the anterior part of the eye. Acute anterior uveitis is associated with the inflammatory diseases collectively known as the seronegative spondyloarthropathies (SpA). These arthritic conditions ....

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Bone Erosion in AS

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New Bone Formation in AS

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Aortic Disease in AS

The aorta is the major blood vessel that is attached to the heart. At the root or point of attachment to the heart, there is a specialised structure called the aortic valve. The Seronegative Spondyloarthropathies and Ankylosing Spondylitis ....

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The Gut in AS

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Lung Disease in AS

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The Hip in AS

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The Shoulder in AS

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The Foot and Ankle in AS

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Enthesis Pain Facts

Pain in joints can arise from the bone. It may arise from joint ligaments or tendons. It may arise from adjacent tissues including muscle and fascia. Occasionally it may arise from diseases outside the joints and bones. A very important cause of joint pain is ....

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Spinal Inflammation in AS

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