This is the primary inflammatory polyenthesitis of the spine. Inflammation in most other tissues leads to their
destruction but this not the case in the spine. The opposite occurs whereby enthesitis is associated with florid tissue
repair and new bone formation at entheses. When inflammation is controlled in Rheumatoid Arthritis then joint damage
usually stops but in Ankylosing Spondylitis damage as determined by loss of function due to the bones knitting together
may actually get worse. Key to understanding these processes is the central role of the enthesis in health and disease.
Ankylosing Spondylitis is associated with enthesitis at multiple sites. It is the commonest inflammatory
polyenthesitis of the spine. It has a predisposition to involve entheses of the spine from the low back
where it most typically starts ....
The sacroiliac joints links the spine to the pelvis and is a major cause of back pain
and especially pain in the low back. The sacroiliac joint is lined by synovium and produces
lubricating synovial fluid ...
Ankylosing spondylitis (AS) typically starts with low back pain in the sacroiliac
joint. This page helps explain why ankylosing spondylitis starts in the sacroiliac joint ....
The chest wall is an incredibly complex region with multiple insertion points that may become inflamed
in Ankylosing Spondylitis and related disorders. The purpose of this page is to explain to both patients and doctors why
chest wall enthesitis is frequently not recognised ....
Acute anterior uveitis causes pain, redness and loss of vision due to inflammation in the anterior
part of the eye. Acute anterior uveitis is associated with the inflammatory diseases collectively known as the seronegative
spondyloarthropathies (SpA). These arthritic conditions ....
New Bone Formation in AS
The aorta is the major blood vessel that is attached to the heart. At the root or point of
attachment to the heart, there is a specialised structure called the aortic valve. The Seronegative
Spondyloarthropathies and Ankylosing Spondylitis ....
The Foot and Ankle in AS
Pain in joints can arise from the bone. It may arise from joint ligaments or tendons.
It may arise from adjacent tissues including muscle and fascia. Occasionally it may arise from diseases
outside the joints and bones. A very important cause of joint pain is ....
Spinal Inflammation in AS
From having no proven therapies, with the possible exception of non-steroidal anti-inflammatory
drugs which are of limited value, the treatment of the spinal polyenthesitis and associated osteitis (bone inflammation) ....